Scientists have discovered that changes in the levels of numerous proteins that migrate from the body’s tissues into circulating blood not only characterize, but quite possibly cause, the phenomenon of ageing.
Researchers from the Stanford University School of Medicine discovered that changes in the levels of numerous proteins that migrate from the body’s tissues into circulating blood not only characterize, but quite possibly cause, the phenomenon of ageing.
The study called “Undulating changes in human plasma proteome profiles across the lifespan,” said the new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.
Scientists measured 2,925 plasma proteins from 4,263 people aged between 18-95 and found that there are three distinct inflection points in the human life cycle.
The Researchers developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age.
Waves of changes in the proteome in the 4th, 7th and 8th decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits, the researchers stated.
This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases, they added.
